Mitochondrial network structure homeostasis and cell death
نویسندگان
چکیده
منابع مشابه
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
ATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as a substrate for ATG12 conjugation. ATG3 is the E2-like enzyme necessary for ATG8/LC3 lipidation during autophagy. ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting i...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2018
ISSN: 1347-9032,1349-7006
DOI: 10.1111/cas.13830